CJC-1295 without DAC

CJC-1295 (WITHOUT DAC) is a laboratory-engineered peptide designed to mimic the activity of growth hormone–releasing hormone (GHRH). In experimental research, it has been utilized to examine mechanisms involved in growth hormone (GH) release and downstream insulin-like growth factor-1 (IGF-1) signaling. The absence of the drug affinity complex (DAC) modification results in a shorter duration of activity, making this variant particularly useful for studies that require transient receptor engagement rather than prolonged hormonal exposure. As a result, CJC-1295 (No DAC) remains an important compound in endocrine and metabolic research settings.

For Research Use Only

This product is supplied strictly for scientific research and laboratory experimentation. It is not intended for human consumption, clinical use, or any form of therapeutic application

Research Areas of Interest

Scientific investigations involving CJC-1295 (No DAC) have explored several endocrine-related pathways, including:

Growth Hormone Secretion Models

Examined for its ability to promote natural, pulsatile GH release without extended activity associated with DAC-modified peptides.

IGF-1 Signaling Research

Studied for its role in influencing IGF-1 response patterns in controlled preclinical environments.

Neuroendocrine Regulation

Utilized to investigate hypothalamic–pituitary communication and hormone signaling coordination.

Comparative Peptide Analysis

Frequently compared with DAC-modified CJC-1295 to evaluate differences in receptor interaction, activity duration, and functional research applications.

Together, these research domains establish CJC-1295 (No DAC) as a valuable tool for studying short-acting growth hormone regulatory mechanisms.

Technical Information

• Peptide Name: CJC-1295 (No DAC)
• Also Known As: Modified GRF (1–29), tetrasubstituted GRF (1–29)
• Molecular Formula: C₁₆₅H₂₇₁N₄₇O₄₆
• Molecular Weight: Approximately 3,367.9 g/mol
• Amino Acid Sequence:

Tyr–Ala–Asp–Ala–Ile–Phe–Thr–Asn–Ser–Tyr–Arg–Lys–Val–Leu–Ala–Gln–Leu–Ser–Ala–Arg–Lys–Leu–Leu–Gln–Asp–Ile–Met–Ser–Arg–Gln–Gln–Gly–Glu–Ser–Asn

• CAS Registry Number: 863288-34-0
• Peptide Type: Synthetic growth hormone–releasing hormone (GHRH) analogue